Gene Therapy for Mesothelioma

Gene therapy is an emerging treatment for mesothelioma. It has been studied to treat many different cancers, including bladder cancer, bone cancer, brain cancer, breast cancer, colon cancer, head and neck cancer, liver cancer, lung cancer, neuroendocrine cancer, ovarian cancer, prostate cancer, soft tissue cancer, and spinal cord cancer. Gene therapy may be especially promising for malignant pleural mesothelioma.

How Gene Therapy Works

Gene therapy involves injecting a viral or bacterial gene into tumor cells that alters or kills tumor cells, thereby preventing them from spreading. The viral or bacterial enzyme gene is most commonly incorporated into tumor cells using a viral vector or a non-viral vector, such as

Bacteria
Bacteriophages: virus-bacteria gene delivery systems
Cationic polymers: positively charged carriers
Cationic liposomes: positively charged sacs
Immunoliposomes: sacs with antibodies attached for targeted delivery to tumor cells
Exosomes: membrane-bound vessels
Nanoparticles: tiny transfer particles
Erythrocyte ghosts: emptied red blood cells
Blood outgrowth endothelial cells and endothelial progenitor cells: blood vessel cells that allow targeted delivery to vascular tumor tissue
Bone marrow stromal cells: bone marrow cells with innate tumor-tracking properties
Neural stem cells: stem cells with innate tumor-targeting properties¹

Benefits and Advantages of Gene Therapy

Gene therapy is a form of targeted cancer treatment. Its effectiveness in treating mesothelioma is still being determined, but studies using increased vector doses show promise in improving survival outcomes. Gene therapy may be especially promising for malignant pleural mesothelioma because it is a relatively localized cancer that can be easily accessed through the chest wall. Moreover, the cancer’s thin layer of mesothelial cells provides a large surface area for rapid and extensive gene transfer.² Unlike some cancer therapies like chemotherapy, gene therapy has few side effects and poses little threat to the surrounding healthy tissue.